tag:blogger.com,1999:blog-7721098568390636553.post7999586809152953242..comments2023-06-06T07:02:56.002-07:00Comments on The Spark of Reason: Polyunsaturated LogicDavehttp://www.blogger.com/profile/18290594860469294453noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-7721098568390636553.post-54684802442202607652008-03-05T11:52:00.000-08:002008-03-05T11:52:00.000-08:00Hi DaveI guess that it’s precisely the absence of ...Hi Dave<BR/><BR/>I guess that it’s precisely the absence of any probable biochemical model that has helped strengthening the cholesterol hypothesis all these years. The model can never be found, so it can be pursued for ever. <BR/><BR/>What I find even more appalling is the fact that in spite of all the sound evidence actually explaining many of the mechanism involved in atherosclerosis, clearly demonstrating that cholesterol is not the cause, this charade still goes on and on.<BR/><BR/>I believe that most serious researchers must be aware of the situation, and that they put their energy into something more interesting. Cholesterol “science” then is left with the statinators.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7721098568390636553.post-91431514075040979482008-03-05T10:27:00.000-08:002008-03-05T10:27:00.000-08:00Hi Dave! Clicked your link from a comment you lef...Hi Dave! Clicked your link from a comment you left on Low Carb Confidential, and glad I did. This is fascinating stuff (who knew I'd ever be interested in cellular biology?) I'll be checking in regularly, and I really appreciate your comments in our blog to add to the "music." (I wish I could travel forward and confirm the PUFA theory, but unfortunately, the DeLorean was completely destroyed and Doc's back in 1885 with Clara and the kids!)megamashttps://www.blogger.com/profile/17532338743404295138noreply@blogger.comtag:blogger.com,1999:blog-7721098568390636553.post-66190090790823731672008-02-29T12:11:00.000-08:002008-02-29T12:11:00.000-08:00Hi Michael. I remember the Enig/Fallon discussion ...Hi Michael. I remember the Enig/Fallon discussion of PUFA and cell membrane fluidity, should have been less lazy and referenced it. I'm curious as to the level of evidence for this hypothesis, if anybody can fill in the blanks.<BR/><BR/>I don't know that I've seen the related hypothesis of SFA displacing cholesterol in the cell membrane, but it's possible I read it somewhere else, forgot I read it, and then had it bubble up. And unless there's some evidence, it remains speculation of course.<BR/><BR/>I'm still amazed at the apparent paucity of evidence for any sort of molecular/cellular mechanism for which the saturation index of dietary fat would influence serum cholesterol. There's so much detailed info known about metabolism, and this is such a big deal (for the majority that believe the lipid hypothesis), you'd think it would have beens studied to death.Davehttps://www.blogger.com/profile/18290594860469294453noreply@blogger.comtag:blogger.com,1999:blog-7721098568390636553.post-4577039306750474832008-02-29T11:53:00.000-08:002008-02-29T11:53:00.000-08:00I enjoyed reading this, it sums it up pretty well ...I enjoyed reading this, it sums it up pretty well I think. Medical sciences need more science!<BR/><BR/>The cell membrane idea has been proposed previously, see e g, The Skinny on Fats by Enig and Fallon; “Along with saturated fats, cholesterol in the cell membrane gives our cells necessary stiffness and stability. When the diet contains an excess of polyunsaturated fatty acids, these replace saturated fatty acids in the cell membrane, so that the cell walls actually become flabby. When this happens, cholesterol from the blood is "driven" into the tissues to give them structural integrity. This is why serum cholesterol levels may go down temporarily when we replace saturated fats with polyunsaturated oils in the diet”.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7721098568390636553.post-8598164234654262732008-02-29T10:34:00.000-08:002008-02-29T10:34:00.000-08:00Ties in with what I read on Chris Masterjohn's sit...Ties in with what I read on Chris Masterjohn's site re cell membranes.<BR/><BR/>And its certainly more plausible than the diet/heart hypothesis!<BR/><BR/>NeilAnonymousnoreply@blogger.com